What Happens With a Ventricular Septal Defect?

The pathogenesis of ventricular septal defect and its complications is inextricably linked with hemodynamics (direction of blood flow). The left ventricle has a massive muscle mass and creates pressure several times higher than that in other chambers of the heart, therefore, when an opening in the interventricular septum is formed, the blood is directed from left to right.

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