Why does myocardial infarction have different severity in different people?

The amount of myocardial damage (and, as a result, its severity) that is caused by coronary occlusion depends on:

  1. the volume of tissue supplied by the affected vessel;
  2. the degree of blockage of the vessel (full or partial occlusion) and its duration;
  3. the volume of blood supplied through the collateral vessels to the affected tissue;
  4. myocardial oxygen demand;
  5. internal (endogenous) factors that can cause early spontaneous lysis (destruction) of an occlusive thrombus;
  6. the adequacy of myocardial blood supply in the infarction zone when blood flow is restored.

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