Brain metastases treatment in 814 Neurosurgery and Oncology clinics worldwide

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814 clinics specializing in Neurosurgery and Oncology providing treatment of Brain metastases Brain metastases are secondary tumors that spread to the brain from primary cancers in other parts of the body. They can cause neurological symptoms and may require treatments such as surgery, radiation therapy, or systemic therapies for management.
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disease worldwide.

Africa · 15
Americas · 176
Asia · 272
Europe · 318
Oceania · 33
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Africa · 15 Americas · 176 Asia · 272 Europe · 318 Oceania · 33
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Prices for popular procedures:
  1. Stereotactic radiation therapy (SRT)
    $2,680
  2. Radiosurgery
    $2,680 - $3,892
  3. CyberKnife radiosurgery
    $2,680 - $3,892
  4. Image-guided radiation therapy (IGRT)
    $2,488 - $3,764
  5. Intensity-modulated radiation therapy (IMRT)
    $2,488 - $3,764
  6. Volumetric modulated arc therapy (VMAT)
    $2,488 - $3,764
  7. Stereotactic spine radiosurgery
    $2,488 - $2,807
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Ufa, Russia
Specializations: Oncology
The center has equipment for PET / CT examinations from one of the leaders in the production of medical equipment. The same equipment is used read more
Prices for popular procedures:
  1. Radiation therapy
    $2,552
  2. Stereotactic radiation therapy (SRT)
    $2,552
  3. Radiosurgery
    $2,552
  4. Radiation therapy for breast cancer
    $2,169 - $3,828
  5. Radiotherapy for prostate cancer
    $2,552
  6. LINAC based stereotactic radiosurgery
    $2,552
  7. Intensity-modulated radiation therapy (IMRT)
    $2,552
  8. Intracavitary brachytherapy
    $2,297
  9. Lumpectomy
    ≈ $1,239
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Balashikha, Russia
Specializations: Oncology
The PET-Technology oncology center in Balashikha was designed, built and equipped as part of a public-private partnership with the Government of the Moscow Region, the read more
Prices for popular procedures:
  1. Radiation therapy
    $2,552
  2. Stereotactic radiation therapy (SRT)
    $2,552
  3. Radiosurgery
    $2,552
  4. Radiation therapy for breast cancer
    $2,169 - $3,828
  5. Radiotherapy for prostate cancer
    $2,552
  6. LINAC based stereotactic radiosurgery
    $2,552
  7. Intensity-modulated radiation therapy (IMRT)
    $2,552
  8. Intracavitary brachytherapy
    $2,297
  9. Lumpectomy
    ≈ $1,239
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Podolsk, Russia
Specializations: Oncology
The PET-Technology Cancer Radiology Center in Podolsk is a modern, comfortable medical facility for patients with any stage of the disease. The center has a read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Radiation therapy for breast cancer
    from $21,750
  3. Radiotherapy for prostate cancer
    from $34,476
  4. Brachytherapy for prostate cancer
    from $53,066
  5. Lumpectomy
    ≈ $7,067
  6. Simple mastectomy
    from $16,915
  7. Partial mastectomy
    from $19,191
  8. Radical mastectomy
    from $16,915
  9. Surgical breast biopsy
    ≈ $4,706
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Helsinki, Finland
Specializations: Oncology
Docrates Cancer Center, based in Helsinki, Finland, is a leading international treatment facility specialising in the diagnostics, treatment and follow-up of cancers. The hospital opened read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Radiosurgery
    by request
  3. Hemicolectomy
    ≈ $19,703
  4. Rectum anterior resection
    ≈ $16,634
  5. Radical prostatectomy
    ≈ $17,069
  6. Transurethral resection of the prostate (TURP)
    ≈ $8,576
  7. Conization
    ≈ $3,508
  8. Open hysterectomy
    ≈ $8,893
  9. Radical nephrectomy
    ≈ $20,764
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Dubai, United Arab Emirates
Specializations: Thoracic surgery, Oncology
Languages: English, Arabic
Mediclinic City Hospital’s Comprehensive Cancer Centre (CCC), is Dubai’s most advanced facility for the diagnosis and treatment of cancer. Built in collaboration with Mediclinic Middle read more
Prices for popular procedures:
  1. Proton therapy
    by request
  2. Childhood vascular tumor treatment
    ≈ $1,379
  3. Chemotherapy for retinoblastoma
    by request
  4. Chemotherapy for eye cancer
    by request
  5. Chemotherapy for head and neck cancer
    by request
  6. Interstitial chemotherapy for brain tumors
    by request
  7. Chemotherapy for soft tissue sarcoma
    by request
  8. Chemotherapy for neuroendocrine tumours (NETs)
    by request
  9. Chemotherapy for neuroblastoma
    by request
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Pozuelo de Alarcón, Spain
Specializations: Oncology
Quirónsalud, the leading hospital group in Spain and Europe, is at the forefront of Oncology by building the first Proton Therapy Center in Spain. One read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Hemicolectomy
    ≈ $9,550
  3. Rectum anterior resection
    ≈ $6,731
  4. Radical prostatectomy
    ≈ $7,389
  5. Transurethral resection of the prostate (TURP)
    ≈ $3,534
  6. Conization
    ≈ $1,523
  7. Open hysterectomy
    ≈ $3,131
  8. Radical nephrectomy
    ≈ $8,912
  9. Loop electrosurgical excision procedure (LEEP)
    ≈ $776
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Medina, Saudi Arabia
Specializations: Vascular surgery, Thoracic surgery, Oncology
King Faisal Specialist Hospital & Research Centre (Gen. Org) Madinah (KFSH&RC-M) is the latest addition to our internationally recognized organization. Our mission at KFSH&RC-M is read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. TomoTherapy
    ≈ $1,341
  3. Stereotactic radiation therapy (SRT)
    by request
  4. Radical prostatectomy
    ≈ $16,764
  5. Transurethral resection of the prostate (TURP)
    ≈ $7,952
  6. Conization
    ≈ $3,458
  7. Open hysterectomy
    ≈ $5,369
  8. Radical nephrectomy
    ≈ $18,175
  9. Loop electrosurgical excision procedure (LEEP)
    ≈ $2,322
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Toulouse, France
Specializations: Thoracic surgery, Oncology
Languages: English, German, Spanish; Castilian
The IUCT Oncopole comprises the Institut Claudius Regaud, a cancer center, and several teams from Toulouse University Hospital Center. The two institutions offer the expertise read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  3. Immune checkpoint inhibitors
    by request
  4. Monoclonal antibodies therapy (mAbs)
    by request
  5. Natural killer (NK) cell therapy
    by request
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São Paulo, Brazil
Specializations: Oncology
Occupying a total area of ​​1,550 m2, we have an infrastructure specially built to ensure the well-being of patients during cancer treatment. Humanism was the read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. TomoTherapy
    ≈ $1,619
  3. CyberKnife radiosurgery
    by request
  4. Hemicolectomy
    ≈ $23,647
  5. Rectum anterior resection
    ≈ $22,542
  6. Radical prostatectomy
    ≈ $21,453
  7. Transurethral resection of the prostate (TURP)
    ≈ $9,905
  8. Conization
    ≈ $4,575
  9. Open hysterectomy
    ≈ $8,752
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Milan, Italy
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Oncology
Languages: Arabic, English, Russian
The IEO (European Institute of Oncology) is one of the world's most prestigious hospitals and the fastest growing comprehensive cancer centre in Europe. IEO integrates read more
Prices for popular procedures:
  1. Radiation therapy
    $198 - $7,068
  2. Stereotactic radiation therapy (SRT)
    $2,894
  3. Brachytherapy for prostate cancer
    $5,303
  4. Radioactive Iodine therapy for thyroid cancer
    $1,649
  5. Hemicolectomy
    $1,406 - $2,447
  6. Rectum anterior resection
    $1,406 - $2,447
  7. Radical prostatectomy
    ≈ $2,883
  8. Transurethral resection of the prostate (TURP)
    ≈ $1,953
  9. Conization
    ≈ $429
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Kazan, Russia
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Oncology
GAUZ "Republican Clinical Oncological Dispensary of the Ministry of Health of the Republic of Tatarstan" named after Professor M.Z. Sigal "is one of the largest read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Stereotactic radiation therapy (SRT)
    by request
  3. Hemicolectomy
    ≈ $17,250
  4. Rectum anterior resection
    ≈ $18,649
  5. Radical prostatectomy
    ≈ $16,764
  6. Transurethral resection of the prostate (TURP)
    ≈ $7,952
  7. Conization
    ≈ $3,458
  8. Open hysterectomy
    ≈ $5,369
  9. Radical nephrectomy
    ≈ $18,175
photo
Marseille, France
Specializations: Vascular surgery, Thoracic surgery, Oncology
The Paoli-Calmettes Institute (IPC) is a center for the fight against cancer, a member of the Unicancer group , governed by the public health code. read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Stereotactic radiation therapy (SRT)
    by request
  3. Radical prostatectomy
    ≈ $10,240
  4. Transurethral resection of the prostate (TURP)
    ≈ $3,151
  5. Radical nephrectomy
    ≈ $6,095
  6. Parotidectomy
    ≈ $1,183
  7. Lumpectomy
    ≈ $1,314
  8. Cervical lymphadenectomy
    ≈ $3,310
  9. Transurethral resection of bladder tumor (TURBT)
    ≈ $2,430
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Chennai, India
Specializations: Thoracic surgery, Orthopedic surgery, Oncology
The Cancer Institute (WIA), as you are aware, is a public charitable voluntary institute dedicated to the care of cancer for for the last 60 read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Radiosurgery
    by request
  3. CyberKnife radiosurgery
    by request
  4. Hemicolectomy
    ≈ $17,250
  5. Rectum anterior resection
    ≈ $18,649
  6. Radical prostatectomy
    ≈ $16,764
  7. Transurethral resection of the prostate (TURP)
    ≈ $7,952
  8. Conization
    ≈ $3,458
  9. Open hysterectomy
    ≈ $5,369
photo
Paris, France
Specializations: Thoracic surgery, Orthopedic surgery, Oncology
The Ambroise Paré, Pierre Cherest and Hartmann Clinics bring together specialized multidisciplinary teams. Regarding the financial aspect of care, every effort is made to ensure read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Radiosurgery
    by request
  3. Hemicolectomy
    ≈ $9,859
  4. Rectum anterior resection
    ≈ $10,155
  5. Radical prostatectomy
    ≈ $8,684
  6. Transurethral resection of the prostate (TURP)
    ≈ $4,268
  7. Conization
    ≈ $1,991
  8. Open hysterectomy
    ≈ $3,659
  9. Radical nephrectomy
    ≈ $9,521
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Buenos Aires, Argentina
Specializations: Cardiac surgery, Thoracic surgery, Orthopedic surgery, Oncology
As of March 14, 1994, the Alexander Fleming Institute opened its doors to medical and scientific excellence. Maximum technical-scientific level and comfort in one of read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Hemicolectomy
    ≈ $1,124
  3. Rectum anterior resection
    ≈ $4,187
  4. Radical prostatectomy
    ≈ $4,451
  5. Transurethral resection of the prostate (TURP)
    ≈ $3,895
  6. Conization
    ≈ $499
  7. Open hysterectomy
    ≈ $1,947
  8. Radical nephrectomy
    ≈ $4,937
  9. Loop electrosurgical excision procedure (LEEP)
    ≈ $523
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Komárno, Slovakia
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Orthopedic surgery, Oncology
With more than 110 years of history is one of the most important health care providers in the region. It provides medical and preventive care read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Fontan procedure
    ≈ $23,055
  3. Patent ductus arteriosus (PDA) ligation in children
    ≈ $20,589
  4. Heart valve replacement
    ≈ $31,020
  5. Heart valve repair
    ≈ $33,443
  6. Transcatheter aortic valve replacement (TAVR)
    ≈ $40,905
  7. Aortic valve replacement (AVR)
    ≈ $32,451
  8. Mitral valve replacement (MVR)
    ≈ $23,231
  9. Truncus arteriosus repair
    ≈ $23,454
photo
Petaling Jaya, Malaysia
Specializations: Cardiac surgery, Vascular surgery, Oncology
Languages: English
KPJ Damansara's team of specialists, nurses, and allied health professionals practise holistic approaches in your general well-being throughout your stay and beyond. The facilities are read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Hemicolectomy
    ≈ $24,081
  3. Rectum anterior resection
    ≈ $20,780
  4. Laparoscopic cholecystectomy
    ≈ $8,182
  5. Total thyroidectomy
    ≈ $9,052
  6. Cholecystectomy
    ≈ $6,952
  7. Lumpectomy
    ≈ $5,863
  8. Simple mastectomy
    ≈ $12,544
  9. Total colectomy
    ≈ $16,908
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Waidhofen an der Ybbs, Austria
Specializations: Cardiac surgery, Vascular surgery, Orthopedic surgery, Oncology
Every hospital stay represents an unfamiliar situation and is associated with fear and worry. That is why human attention is an indispensable factor in the read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Hemicolectomy
    ≈ $3,364
  3. Rectum anterior resection
    ≈ $3,225
  4. Radical prostatectomy
    ≈ $677
  5. Transurethral resection of the prostate (TURP)
    ≈ $2,185
  6. Conization
    ≈ $699
  7. Open hysterectomy
    ≈ $2,052
  8. Radical nephrectomy
    ≈ $4,631
  9. Loop electrosurgical excision procedure (LEEP)
    ≈ $421
photo
São Paulo, Brazil
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Orthopedic surgery, Oncology
Hospital e Maternidade São Luiz Unidade Anália Franco started its activities on March 3, 2008, in the East Zone of São Paulo, with the purpose read more
Prices for popular procedures:
  1. Brain tumors surgery
    ≈ $5,842
  2. Ommaya reservoir placement
    ≈ $3,056
  3. Radiation therapy
    by request
  4. Radiosurgery
    by request
  5. Hemicolectomy
    ≈ $1,124
  6. Rectum anterior resection
    ≈ $4,187
  7. Radical prostatectomy
    ≈ $4,451
  8. Transurethral resection of the prostate (TURP)
    ≈ $3,895
  9. Conization
    ≈ $499
photo
Bratislava, Slovakia
Specializations: Thoracic surgery, Neurosurgery, Oncology
The National Oncology Institute (NOÚ) is a specialized hospital focused on the provision of comprehensive health oncology care in the scope of specialized outpatient health read more

Clinics grouping by rating

Clinic with the highest rating of 5 — AXIS Clinic, Moscow in Moscow, Russia and 3 more, clinic with the most reviews number of 35757 — Aster CMI hospital in Bengaluru, India.

With rating 4.0 and over — 288 clinics .

Countries with the highest number of clinics treating the diseases:

Brain metastases:

Related procedures:

Metastatic Brain Tumors: Overview and Treatment

Disease Types & Epidemiology

How common is the disease?

Cancer cells begin growing elsewhere in the body and then travel to the brain to form metastatic brain tumors. For example, cancers of the lung, breast, colon, and skin (melanoma) frequently spread to the brain via the bloodstream or a magnetic-like attraction to other organs of the body. All metastatic brain tumors are, by definition, malignant and can genuinely be called “secondary brain cancer” or “brain metastases.”

Each year, more than 94,000 people in the United States are diagnosed with a primary brain tumor, and more than twice that number are diagnosed with a metastatic tumor. The incidence of brain metastases appears to be increasing [Amsbaugh & Kim, 2023]. In 2023, this number reached 200,000 patients [braintumor.org].

Almost all kinds of cancer have been associated with the risk of brain metastases. The most common oncology diseases are melanoma, lung, breast, renal, and colorectal cancers [AANS 2024; Redmer 2018; Lamba et al. 2021]. About 10-30% of cancer patients may develop brain metastases during their disease history [hopkinsmedicine.org].

Metastatic brain tumors usually contain the same type of cancer cells found at the primary site. For example, small-cell lung cancer that moves to the brain forms small-cell cancer in the brain. Squamous-cell head and neck cancer forms squamous-cell cancer in the brain. Brain metastasis can present as a single or multiple tumor.

Clinical Manifestation & Symptoms

What signs should one anticipate while suspecting metastatic brain cancer?

The symptoms of metastatic brain tumors are the same as those of primary brain tumors and are related to the location of the tumor within the brain. Each part of the brain controls specific body functions. Symptoms appear when areas of the brain can no longer function properly. Headache and seizures are the two most common symptoms. Disturbance in the way one thinks and processes thoughts (cognition) is another common symptom of a metastatic brain tumor. Cognitive challenges might include difficulty with memory (especially short-term memory) or personality and behavior changes. Motor problems, such as weakness on one side of the body or an unbalanced walk, can be related to a tumor located in the part of the brain that controls these functions.

Metastatic tumors in the spine may cause back pain, weakness, or changes in sensation in an arm or leg, or may cause loss of bladder/bowel control. Both cognitive and motor problems may also be caused by edema, or swelling, around the tumor.

Diagnostic Route

When, where, and how should secondary brain cancer be detected?

Brain scans such as Computer Tomography (CT scan – fast test), or Magnetic Resonance Tomography (MRI scan – gold standard), and lumbar puncture (spinal tap) are the tools to take a broad picture of the lesion number and metastatic origin of the brain tumor.

The lumbar puncture is used to obtain a cerebrospinal fluid (CSF) sample. This procedure is usually avoided if there is any indication of increased intracranial pressure because of the risk of herniation, or the brain’s bulging through an opening in a membrane, muscle, or bone.

The sample of CSF is examined in a laboratory to determine if tumor cells, infection, protein, or blood is present. The presence of tumor cells in the CSF indicates tumor spread. That information is used for tumor staging and helps the doctor determine appropriate treatment choices.

In addition to tumor cells and substances that indicate the presence of a tumor, the CSF may also be examined for the presence of known tumor markers. Some common biomarkers include the following [ESMO Guidelines, 2021]:

  • MGMT & EGFRvIII – glioblastoma (primary brain cancer);
  • IDH1/IDH2 – primary brain cancer or blood cancer, such as acute myelogenous leukemia or myelodysplastic syndromes;
  • 1p/19q – oligodendroglioma (primary brain cancer);
  • EGFR – secondary brain cancer marker associated with non-brain cancer origins of the tumor, such as lung, pancreas, head & neck, liver, or others.
  • TERT – secondary brain cancer marker associated with bladder, colorectal, lung, thyroid, head & neck cancer, as well as melanoma and soft tissue sarcoma.

Suppose the MRI brain scan shows a suspected brain tumor. In that case, the next step of a patient is likely to be a consultation with a neurosurgeon, radiation oncologist, or medical/neuro-oncologist. After analyzing the MRI scans, the neurosurgeon determines if the tumor(-s) can be surgically removed or if other treatment options would be more reasonable.

Treatment Approaches

What are the options for managing metastatic brain cancer?

The three main categories of treatments include surgery, radiation (whole brain radiation, stereotactic radiosurgery, or both), and medical therapy (chemotherapy, targeted therapy, or immune-based therapy). More than one type of treatment might be suggested.

Early treatment of a patient’s brain tumor focuses on controlling symptoms, such as swelling of the brain and/or seizures. If the patient has a limited number of metastatic brain tumors (generally one to three tumors, or a small number of lesions that are close to each other) and if the primary cancer is treatable and under control, the brain metastases’ treatment plan may include surgery to confirm the diagnosis and remove the tumor, followed by a form of radiation therapy (Gamma Knife). This step is generally followed by medical therapy (corticosteroids, anti-seizure medications) that may impact not only the primary cancer but also the metastatic brain tumor.

If there are multiple brain metastases (four or more brain tumors), traditionally hippocampal sparing whole-brain radiation therapy with memantine has been recommended; however, recently, the use of radiosurgery or medical treatment has increased. The stereotactic surgery method is standard for patients with large lesions (one to ten brain tumors) [Yamamoto et al., 2017].

If there is a question about the scan results or the diagnosis, a biopsy or microsurgical resection to remove the brain tumors may be done. This approach allows physicians to confirm that the brain tumors are related to the primary cancer. Metastases to the spine may be treated with radiation therapy alone or with surgery plus radiation.

Prognosis

How does cutting-edge science improve the lifespan and quality of life for those with the disease?

The number of metastases is not the sole predictor of how well the patient might do following treatment. Their neurological function (how the patient is affected by the brain metastases), the status of the primary cancer site (i.e., the presence/absence of metastases in other parts of the body), type of cancer, and the genetic alterations in cancer also appear to influence overall survival. Treatment decisions consider long-term survival possibilities, the patient’s quality of life during and after treatment, and cognition concerns.

Local recurrence following surgical resection, the historical standard in patients with good performance status is 57% in 12 months after the operation [Lancet Oncology, 2017]. Local control might be improved via whole-brain radiotherapy or postoperative stereotactic radiosurgery, giving a patient one year as the median overall survival period [Lancet Oncology, 2018].

  • Isabella Gonzalez, M.D.
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