Bone metastases treatment in 814 Oncology clinics worldwide

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814 clinics specializing in Oncology providing treatment of Bone metastases Bone metastases refer to the spread of cancer from another primary site to the bones. It can cause bone pain, fractures, and other complications, and may require treatments such as radiation therapy, targeted therapy, or surgery for management.
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disease worldwide.

Africa · 15
Americas · 178
Asia · 255
Europe · 331
Oceania · 35
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Africa · 15 Americas · 178 Asia · 255 Europe · 331 Oceania · 35
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Prices for popular procedures:
  1. Targeted therapy
    by request
  2. Chemotherapy for bone cancer
    by request
  3. Chemotherapy for melanoma
    by request
  4. Chemotherapy for endometrial cancer
    by request
  5. Chemotherapy for gallbladder cancer
    by request
  6. Chemotherapy for colorectal cancer
    by request
  7. Chemotherapy for eye cancer
    by request
  8. Chemotherapy for myeloma
    by request
  9. Chemotherapy for non-melanoma skin cancer
    by request
photo
Belo Horizonte, Brazil
Specializations: Oncology
Founded in 1999, Oncocentro was born with the purpose of offering an integral, welcoming and interdisciplinary service. Over the years, it has become a reference read more
Prices for popular procedures:
  1. CyberKnife radiosurgery
    $2,680 - $3,892
  2. Image-guided radiation therapy (IGRT)
    $2,488 - $3,764
  3. Intensity-modulated radiation therapy (IMRT)
    $2,488 - $3,764
  4. Volumetric modulated arc therapy (VMAT)
    $2,488 - $3,764
  5. Stereotactic radiation therapy (SRT)
    $2,680
  6. Radiosurgery
    $2,680 - $3,892
  7. Stereotactic spine radiosurgery
    $2,488 - $2,807
photo
Ufa, Russia
Specializations: Oncology
The center has equipment for PET / CT examinations from one of the leaders in the production of medical equipment. The same equipment is used read more
Prices for popular procedures:
  1. Radiation therapy
    $2,552
  2. Chemotherapy for bone cancer
    by request
  3. Radiation therapy for breast cancer
    $2,169 - $3,828
  4. Radiotherapy for prostate cancer
    $2,552
  5. LINAC based stereotactic radiosurgery
    $2,552
  6. Intensity-modulated radiation therapy (IMRT)
    $2,552
  7. Stereotactic radiation therapy (SRT)
    $2,552
  8. Radiosurgery
    $2,552
  9. Intracavitary brachytherapy
    $2,297
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Balashikha, Russia
Specializations: Oncology
The PET-Technology oncology center in Balashikha was designed, built and equipped as part of a public-private partnership with the Government of the Moscow Region, the read more
Prices for popular procedures:
  1. Radiation therapy
    $2,552
  2. Chemotherapy for bone cancer
    by request
  3. Radiation therapy for breast cancer
    $2,169 - $3,828
  4. Radiotherapy for prostate cancer
    $2,552
  5. LINAC based stereotactic radiosurgery
    $2,552
  6. Intensity-modulated radiation therapy (IMRT)
    $2,552
  7. Stereotactic radiation therapy (SRT)
    $2,552
  8. Radiosurgery
    $2,552
  9. Intracavitary brachytherapy
    $2,297
photo
Podolsk, Russia
Specializations: Oncology
The PET-Technology Cancer Radiology Center in Podolsk is a modern, comfortable medical facility for patients with any stage of the disease. The center has a read more
Prices for popular procedures:
  1. Targeted therapy
    by request
  2. Chemotherapy for bone cancer
    by request
  3. Chemotherapy for liver cancer
    by request
  4. Chemotherapy for brain cancer
    by request
  5. Chemotherapy for lymphoma
    by request
  6. Chemotherapy for gallbladder cancer
    by request
  7. Chemotherapy for eye cancer
    by request
  8. Chemotherapy for myeloma
    by request
  9. Chemotherapy for melanoma
    by request
photo
Budapest, Hungary
Specializations: Oncology
In the Oncology Profile of the Internal Medicine and Oncology Clinic patients with so-called solid tumors are treated with medication. The center offers traditional chemotherapy read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Radionuclide therapy
    by request
  3. Chemotherapy for bone cancer
    by request
  4. Radiation therapy for breast cancer
    from $21,750
  5. Radiotherapy for prostate cancer
    from $34,476
  6. Brachytherapy for prostate cancer
    from $53,066
  7. Lumpectomy
    ≈ $7,067
  8. Simple mastectomy
    from $16,915
  9. Partial mastectomy
    from $19,191
photo
Helsinki, Finland
Specializations: Oncology
Docrates Cancer Center, based in Helsinki, Finland, is a leading international treatment facility specialising in the diagnostics, treatment and follow-up of cancers. The hospital opened read more
Prices for popular procedures:
  1. Targeted therapy
    by request
  2. Radiation therapy
    by request
  3. Chemotherapy for bone cancer
    by request
  4. Hemicolectomy
    ≈ $19,703
  5. Rectum anterior resection
    ≈ $16,634
  6. Radical prostatectomy
    ≈ $17,069
  7. Transurethral resection of the prostate (TURP)
    ≈ $8,576
  8. Conization
    ≈ $3,508
  9. Open hysterectomy
    ≈ $8,893
photo
Dubai, United Arab Emirates
Specializations: Thoracic surgery, Oncology
Languages: English, Arabic
Mediclinic City Hospital’s Comprehensive Cancer Centre (CCC), is Dubai’s most advanced facility for the diagnosis and treatment of cancer. Built in collaboration with Mediclinic Middle read more
Prices for popular procedures:
  1. Chemotherapy for bone cancer
    by request
  2. Childhood vascular tumor treatment
    ≈ $1,379
  3. Proton therapy
    by request
  4. Chemotherapy for retinoblastoma
    by request
  5. Chemotherapy for eye cancer
    by request
  6. Chemotherapy for head and neck cancer
    by request
  7. Interstitial chemotherapy for brain tumors
    by request
  8. Chemotherapy for soft tissue sarcoma
    by request
  9. Chemotherapy for neuroendocrine tumours (NETs)
    by request
photo
Pozuelo de Alarcón, Spain
Specializations: Oncology
Quirónsalud, the leading hospital group in Spain and Europe, is at the forefront of Oncology by building the first Proton Therapy Center in Spain. One read more
Prices for popular procedures:
  1. Surgery for bone cancer
    ≈ $3,718
  2. Targeted therapy
    by request
  3. Radiation therapy
    by request
  4. Chemotherapy for bone cancer
    by request
  5. Hemicolectomy
    ≈ $9,550
  6. Rectum anterior resection
    ≈ $6,731
  7. Radical prostatectomy
    ≈ $7,389
  8. Transurethral resection of the prostate (TURP)
    ≈ $3,534
  9. Conization
    ≈ $1,523
photo
Medina, Saudi Arabia
Specializations: Vascular surgery, Thoracic surgery, Oncology
King Faisal Specialist Hospital & Research Centre (Gen. Org) Madinah (KFSH&RC-M) is the latest addition to our internationally recognized organization. Our mission at KFSH&RC-M is read more
Prices for popular procedures:
  1. Surgery for bone cancer
    ≈ $12,157
  2. Targeted therapy
    by request
  3. Radiation therapy
    by request
  4. Radionuclide therapy
    by request
  5. Chemotherapy for bone cancer
    by request
  6. Radical prostatectomy
    ≈ $16,764
  7. Transurethral resection of the prostate (TURP)
    ≈ $7,952
  8. Conization
    ≈ $3,458
  9. Open hysterectomy
    ≈ $5,369
photo
Toulouse, France
Specializations: Thoracic surgery, Oncology
Languages: English, German, Spanish; Castilian
The IUCT Oncopole comprises the Institut Claudius Regaud, a cancer center, and several teams from Toulouse University Hospital Center. The two institutions offer the expertise read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  3. Immune checkpoint inhibitors
    by request
  4. Monoclonal antibodies therapy (mAbs)
    by request
  5. Natural killer (NK) cell therapy
    by request
photo
São Paulo, Brazil
Specializations: Oncology
Occupying a total area of ​​1,550 m2, we have an infrastructure specially built to ensure the well-being of patients during cancer treatment. Humanism was the read more
Prices for popular procedures:
  1. Radiation therapy
    by request
  2. CyberKnife radiosurgery
    by request
  3. Chemotherapy for bone cancer
    by request
  4. Hemicolectomy
    ≈ $23,647
  5. Rectum anterior resection
    ≈ $22,542
  6. Radical prostatectomy
    ≈ $21,453
  7. Transurethral resection of the prostate (TURP)
    ≈ $9,905
  8. Conization
    ≈ $4,575
  9. Open hysterectomy
    ≈ $8,752
photo
Milan, Italy
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Oncology
Languages: Arabic, English, Russian
The IEO (European Institute of Oncology) is one of the world's most prestigious hospitals and the fastest growing comprehensive cancer centre in Europe. IEO integrates read more
Prices for popular procedures:
  1. Targeted therapy
    by request
  2. Radiation therapy
    $198 - $7,068
  3. Chemotherapy for bone cancer
    by request
  4. Brachytherapy for prostate cancer
    $5,303
  5. Stereotactic radiation therapy (SRT)
    $2,894
  6. Radioactive Iodine therapy for thyroid cancer
    $1,649
  7. Hemicolectomy
    $1,406 - $2,447
  8. Rectum anterior resection
    $1,406 - $2,447
  9. Radical prostatectomy
    ≈ $2,883
photo
Kazan, Russia
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Oncology
GAUZ "Republican Clinical Oncological Dispensary of the Ministry of Health of the Republic of Tatarstan" named after Professor M.Z. Sigal "is one of the largest read more
Prices for popular procedures:
  1. Surgery for bone cancer
    ≈ $12,157
  2. Targeted therapy
    by request
  3. Radiation therapy
    by request
  4. Chemotherapy for bone cancer
    by request
  5. Hemicolectomy
    ≈ $17,250
  6. Rectum anterior resection
    ≈ $18,649
  7. Radical prostatectomy
    ≈ $16,764
  8. Transurethral resection of the prostate (TURP)
    ≈ $7,952
  9. Conization
    ≈ $3,458
photo
Marseille, France
Specializations: Vascular surgery, Thoracic surgery, Oncology
The Paoli-Calmettes Institute (IPC) is a center for the fight against cancer, a member of the Unicancer group , governed by the public health code. read more
Prices for popular procedures:
  1. Chemotherapy for bone cancer
    by request
  2. Conization
    ≈ $2,068
  3. Open hysterectomy
    ≈ $2,611
  4. Loop electrosurgical excision procedure (LEEP)
    ≈ $1,153
  5. Total laparoscopic hysterectomy (TLH)
    $1,582
  6. Laparoscopic cholecystectomy
    ≈ $1,543
  7. Total gastrectomy
    ≈ $18,454
  8. Total thyroidectomy
    ≈ $4,771
  9. Cholecystectomy
    ≈ $3,060
photo
Reynosa, Mexico
Specializations: Cardiac surgery, Vascular surgery, Oncology
Languages: English
The quality of CHRISTUS MUGUERZA on the Mexican border At CHRISTUS MUGUERZA Hospital Reynosa we provide high quality medical services to the Tamaulipas border community read more
Prices for popular procedures:
  1. Chemotherapy for bone cancer
    by request
  2. Hemicolectomy
    ≈ $4,516
  3. Rectum anterior resection
    ≈ $3,490
  4. Conization
    ≈ $735
  5. Open hysterectomy
    ≈ $1,644
  6. Loop electrosurgical excision procedure (LEEP)
    ≈ $411
  7. Total laparoscopic hysterectomy (TLH)
    ≈ $1,795
  8. Laparoscopic cholecystectomy
    ≈ $1,449
  9. Total gastrectomy
    ≈ $6,898
photo
Chittagong, Bangladesh
Specializations: Thoracic surgery, Oncology
Chattogram Maa-O-Shishu Hospital is a 650-bedded hospital, which includes Paediatrics Medicine, Neonatology, Pediatric Surgery, Paediatric Neorology, General Surgery, Obstetrics & Gynaecology, Medicine & it's sub-specialists. read more
Prices for popular procedures:
  1. Surgery for bone cancer
    ≈ $4,853
  2. Soft tissue tumor removal
    ≈ $1,283
  3. Pelvic bone resection
    ≈ $3,837
  4. Total knee replacement (Unilateral)
    ≈ $5,594
  5. Total hip replacement (Unilateral)
    ≈ $5,033
  6. Total shoulder replacement
    ≈ $9,255
  7. Hip osteotomy
    ≈ $3,740
  8. Shoulder arthroscopy
    ≈ $1,865
  9. SLAP repair surgery
    ≈ $4,114
photo
Budapest, Hungary
Specializations: Thoracic surgery, Orthopedic surgery, Oncology
The Orthopedic Clinic is one of the most outstanding institutions in Hungary. In addition to patient care, our clinic also carries out a lot of read more
Prices for popular procedures:
  1. Surgery for bone cancer
    ≈ $4,652
  2. Targeted therapy
    by request
  3. Radiation therapy
    by request
  4. Radical prostatectomy
    ≈ $10,240
  5. Transurethral resection of the prostate (TURP)
    ≈ $3,151
  6. Radical nephrectomy
    ≈ $6,095
  7. Parotidectomy
    ≈ $1,183
  8. Lumpectomy
    ≈ $1,314
  9. Cervical lymphadenectomy
    ≈ $3,310
photo
Chennai, India
Specializations: Thoracic surgery, Orthopedic surgery, Oncology
The Cancer Institute (WIA), as you are aware, is a public charitable voluntary institute dedicated to the care of cancer for for the last 60 read more
Prices for popular procedures:
  1. Surgery for bone cancer
    ≈ $12,865
  2. Chemotherapy for bone cancer
    by request
  3. Hemicolectomy
    $14,011
  4. Rectum anterior resection
    ≈ $16,901
  5. Radical prostatectomy
    ≈ $15,560
  6. Transurethral resection of the prostate (TURP)
    ≈ $6,033
  7. Conization
    ≈ $3,159
  8. Open hysterectomy
    from $8,801
  9. Radical nephrectomy
    ≈ $13,700
photo
Melbourne, Australia
Specializations: Thoracic surgery, Orthopedic surgery, Oncology
Languages: Arabic, Croatian, Italian, Serbian, Somali, Turkish, Vietnamese, Spanish; Castilian, Chinese, Greek, Modern
St Vincent’s Hospitals Australia has a rich tradition of providing progressive and excellent health care. We combine the latest technology with exceptional and compassionate medical, read more
Prices for popular procedures:
  1. Surgery for bone cancer
    ≈ $12,157
  2. Radiation therapy
    by request
  3. CyberKnife radiosurgery
    by request
  4. Chemotherapy for bone cancer
    by request
  5. Hemicolectomy
    ≈ $17,250
  6. Rectum anterior resection
    ≈ $18,649
  7. Radical prostatectomy
    ≈ $16,764
  8. Transurethral resection of the prostate (TURP)
    ≈ $7,952
  9. Conization
    ≈ $3,458
photo
Paris, France
Specializations: Thoracic surgery, Orthopedic surgery, Oncology
The Ambroise Paré, Pierre Cherest and Hartmann Clinics bring together specialized multidisciplinary teams. Regarding the financial aspect of care, every effort is made to ensure read more

Clinics grouping by rating

Clinic with the highest rating of 5 — Berkana clinic in Moscow, Russia and 3 more, clinic with the most reviews number of 35757 — Aster CMI hospital in Bengaluru, India.

With rating 4.0 and over — 288 clinics .

Countries with the highest number of clinics treating the diseases:

Bone metastases:

Related procedures:

Bone Metastases: Overview

Disease Types

What are the bone metastases?

Bone metastases occur when cancer cells spread from their original site to the bones. This is a common complication of advanced cancers, particularly breast, prostate, and lung cancers.

Approximately 95% of patients with multiple myeloma, 70-85% with advanced breast or prostate cancer, and 40% of those with advanced lung or kidney cancer will develop bone metastases [Nature, 2020].

The spine, pelvis, ribs, and long bones of the arms and legs are the most frequent sites affected by this metastatic spread. Bone metastases can lead to significant health issues, including severe pain, fractures, and high calcium levels in the blood, which can be life-threatening if not managed properly.

Causes & Risk Factors

What is the primary issue of bone metastases?

The main problem with bone metastases is that cancer cells, once they spread to the bones, disrupt the normal bone remodeling process. Healthy bones are continuously in a balanced cycle of breakdown and formation. However, metastatic cancer cells can produce chemicals that overstimulate osteoclasts or osteoblasts, weakening bones or abnormal bone growth. Some cancers, such as breast and prostate, have a greater tendency to spread to the bones, partly due to the favorable conditions in the bone microenvironment for tumor growth.

Clinical Manifestation & Symptoms

What signs should one anticipate while suspecting bone metastases?

Bone metastases can occur in any bone but most often affect the spine, pelvis, ribs, and long bones. Patients with bone metastases frequently experience pain in the affected bone. The metastases can also lead to heavy complications like bone fractures or spinal cord compression, which requires urgent medical attention. Excess calcium in the blood from bone breakdown can cause nausea, confusion, and kidney problems [Cancer.org, 2024].

More severe complications of bone metastasis may involve:

  • Dehydration, confusion, vomiting, abdominal pain, and constipation.
  • Increased infection risk, breathlessness, paleness, bruising, and bleeding (due to low healthy blood cell levels in the bone marrow).
  • Pain, weakness, numbness, paralysis, loss of sensation in the legs, and incontinence.

Diagnostic Route

When, where, and how should bone metastasis be detected?

Diagnosing bone metastases typically involves a combination of imaging studies and laboratory tests [NIH, 2023]:

  • Imaging techniques, such as X-rays, bone scans, MRI, CT scans, and PET scans, are used to detect the presence and extent of bone metastases.
  • Bone biopsy may be performed to confirm the diagnosis and determine the type of cancer.
  • Laboratory tests like blood tests can assess calcium levels and other markers indicating bone turnover or cancer progression.

Treatment Approaches

What are the options for managing bone metastasis?

Diagnosing bone metastases typically involves a combination of imaging studies and laboratory tests:

  • Imaging Techniques: X-rays, bone scans, MRI, CT scans, and PET scans are used to detect the presence and extent of bone metastases.
  • Bone Biopsy: In some cases, a biopsy may be performed to confirm the diagnosis and determine the type of cancer.
  • Laboratory Tests: Blood tests can assess calcium levels and other markers indicating bone turnover or cancer progression.

Treatments for bone metastases vary depending on the underlying cancer and the size and location of the metastases. Treatment is usually palliative, meaning the goals are to slow the progression of cancer, reduce symptoms, and improve quality of life. It's important to understand that treatment of bone metastases is rarely curative. The oncologist may recommend one or more of the following approaches:

Radiotherapy uses ionizing radiation to damage the DNA of cancerous cells, causing them to die. It uses external beams aimed at the area of bone metastasis and can be very effective in relieving pain. This primary treatment for localized bone pain can reduce about 70-80% of patients. Radiotherapy is also used to relieve pressure on the spinal cord in cases of spinal cord compression. It is often used after surgical treatments, such as for spinal cord compression and to fix or prevent fractures of the arms or legs [ASTRO, 2024].

Surgical treatment for bone metastases may be considered if there is spinal cord compression, severe pain, and/or a bone fracture caused by bone metastasis. Radiotherapy may also be received after surgery to help strengthen the bone. Whether surgery is recommended depends on which bone is affected, where the cancer is located, what other cancer treatments are being received, and the patient's overall health.

Bone-targeted agents treat bone metastases arising from all types of cancer. These drugs work by reducing bone resorption, thereby helping to strengthen bones. They can reduce bone pain, fracture risk, and calcium levels. It's important to understand that bone-targeted agents are not anticancer therapies, but they can maintain or improve quality of life by reducing pain and complications associated with bone metastases.

Two types of bone-targeted medications are used:

  1. Denosumab is a monoclonal antibody that blocks a protein called RANKL, reducing bone resorption.
  2. Bisphosphonates target areas of high bone turnover, causing osteoclast cells to die and reducing bone resorption. Examples include zoledronate, pamidronate, clodronate, and ibandronate.

Prognosis & Follow-up

How does cutting-edge science improve the lifespan and quality of life for those with bone metastases?

The prognosis for patients with bone metastases can vary greatly, depending on the type of primary cancer, the degree of bone involvement, and the patient's overall health. Generally, the presence of bone metastases suggests advanced disease and a less favorable prognosis. However, with contemporary treatment options, many patients can achieve meaningful pain relief and enhanced quality of life. Five-year survival rates for those with bone metastases tend to be lower, ranging from 10-40%, depending on the specific cancer type [Yang et al., 2023].

What treatments are available to prevent bone metastases?

Bisphosphonate treatment may be recommended in some circumstances to help prevent the development of bone metastases. This can be particularly important for patients considered at high risk of their cancer returning after treatment. However, the best evidence for the benefits of this type of preventative treatment has been observed in post-menopausal women with early-stage breast cancer. Currently, treatment for the prevention of bone metastases is not recommended in any other type of cancer apart from breast cancer.

Individuals diagnosed with early-stage breast cancer who are post-menopausal (or pre-menopausal and receiving a gonadotropin-releasing hormone analog) and are considered at high risk of their cancer returning may be prescribed a bisphosphonate (usually zoledronate, clodronate or ibandronate). Bisphosphonate treatment typically starts at the same time as other systemic therapies (such as chemotherapy) and continues for 2-5 years. Bisphosphonates can also lower the risk of treatment-induced bone loss [Tsukamoto et al., 2021].

What is cancer treatment-related bone loss?

The rate of bone loss naturally increases with age in both men and women. However, some cancer treatments can accelerate this bone loss, leading to osteoporosis. These treatments include:

  • Hormone therapy for breast cancer that reduces estrogen levels: long-term use of these drugs can cause bone loss and increase the risk of fractures. Not all hormone therapies for breast cancer cause this issue.

  • Hormone therapy for prostate cancer: drugs that lower testosterone levels can lead to bone loss.

  • Chemotherapy: certain types can affect the ovaries or testicles, reducing estrogen in women and testosterone in men, resulting in bone loss.

  • High-dose or long-term steroid treatment can cause bone loss.

  • Removal of both testicles in men or the ovaries before menopause in women reduces hormone levels and leads to bone loss.

  • Radiotherapy of the ovaries before menopause lowers estrogen levels and can cause bone loss. Radiotherapy of the pelvic area can also make bones unable to cope with regular activity, increasing fracture risk.

  • Not all cancer treatments increase the rate of bone loss. The oncologist can explain if a specific treatment puts the patient at risk of osteoporosis.

What therapies are available to prevent cancer treatment-related bone loss?

Individuals receiving cancer treatments known to accelerate bone loss can take several steps to reduce the risk of osteoporosis:

  • Stop smoking;
  • Reduce alcohol intake;
  • Eat a calcium-rich diet;
  • Engage in weight-bearing exercises;
  • Take a vitamin D supplement daily.

For women on aromatase inhibitors or undergoing ovarian function suppression for breast cancer and men on androgen deprivation therapy for prostate cancer, bone-targeted agents may be recommended if there is a risk of osteoporosis. These drugs reduce bone resorption, thereby strengthening bones and lowering fracture risk.

Two types of bone-targeted agents used in this context are Denosumab and Bisphosphonates drug class [Yang et al., 2023].

  • Isabella Gonzalez, M.D.
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