Chronic lymphocytic leukemia (CLL) treatment in 752 Oncology clinics worldwide

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752 clinics specializing in Oncology providing treatment of Chronic lymphocytic leukemia (CLL) Chronic lymphocytic leukemia (CLL) is a type of cancer where abnormal lymphocytes accumulate in the blood and bone marrow. It can cause fatigue, swollen lymph nodes, and may require chemotherapy, targeted therapies, or stem cell transplantation for treatment.
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disease worldwide.

Africa · 11
Americas · 165
Asia · 231
Europe · 311
Oceania · 34
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Africa · 11 Americas · 165 Asia · 231 Europe · 311 Oceania · 34
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Prices for popular procedures:
  1. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  2. Targeted therapy
    by request
  3. Chemotherapy for leukemia
    by request
  4. Monoclonal antibodies therapy (mAbs)
    by request
  5. Chemotherapy for melanoma
    by request
  6. Chemotherapy for endometrial cancer
    by request
  7. Chemotherapy for gallbladder cancer
    by request
  8. Chemotherapy for colorectal cancer
    by request
  9. Chemotherapy for bone cancer
    by request
photo
Belo Horizonte, Brazil
Specializations: Oncology
Founded in 1999, Oncocentro was born with the purpose of offering an integral, welcoming and interdisciplinary service. Over the years, it has become a reference read more
Prices for popular procedures:
  1. Chemotherapy for leukemia
    by request
  2. Radiation therapy for breast cancer
    $2,098 - $3,703
  3. Radiotherapy for prostate cancer
    $2,469
  4. LINAC based stereotactic radiosurgery
    $2,469
  5. Intensity-modulated radiation therapy (IMRT)
    $2,469
  6. Stereotactic radiation therapy (SRT)
    $2,469
  7. Radiosurgery
    $2,469
  8. Intracavitary brachytherapy
    $2,222
  9. Lumpectomy
    ≈ $1,199
photo
Balashikha, Russia
Specializations: Oncology
The PET-Technology oncology center in Balashikha was designed, built and equipped as part of a public-private partnership with the Government of the Moscow Region, the read more
Prices for popular procedures:
  1. Chemotherapy for leukemia
    by request
  2. Radiation therapy for breast cancer
    $2,098 - $3,703
  3. Radiotherapy for prostate cancer
    $2,469
  4. LINAC based stereotactic radiosurgery
    $2,469
  5. Intensity-modulated radiation therapy (IMRT)
    $2,469
  6. Stereotactic radiation therapy (SRT)
    $2,469
  7. Radiosurgery
    $2,469
  8. Intracavitary brachytherapy
    $2,222
  9. Lumpectomy
    ≈ $1,199
photo
Podolsk, Russia
Specializations: Oncology
The PET-Technology Cancer Radiology Center in Podolsk is a modern, comfortable medical facility for patients with any stage of the disease. The center has a read more
Prices for popular procedures:
  1. Targeted therapy
    by request
  2. Chemotherapy for leukemia
    by request
  3. Chemotherapy for liver cancer
    by request
  4. Chemotherapy for brain cancer
    by request
  5. Chemotherapy for lymphoma
    by request
  6. Chemotherapy for gallbladder cancer
    by request
  7. Chemotherapy for eye cancer
    by request
  8. Chemotherapy for myeloma
    by request
  9. Chemotherapy for melanoma
    by request
photo
Budapest, Hungary
Specializations: Oncology
In the Oncology Profile of the Internal Medicine and Oncology Clinic patients with so-called solid tumors are treated with medication. The center offers traditional chemotherapy read more
Prices for popular procedures:
  1. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  2. Chemotherapy for leukemia
    by request
  3. Monoclonal antibodies therapy (mAbs)
    by request
  4. Radiation therapy for breast cancer
    from $21,602
  5. Radiotherapy for prostate cancer
    from $34,240
  6. Brachytherapy for prostate cancer
    from $52,703
  7. Lumpectomy
    ≈ $7,020
  8. Simple mastectomy
    from $16,799
  9. Partial mastectomy
    from $19,060
photo
Helsinki, Finland
Specializations: Oncology
Docrates Cancer Center, based in Helsinki, Finland, is a leading international treatment facility specialising in the diagnostics, treatment and follow-up of cancers. The hospital opened read more
Prices for popular procedures:
  1. Autologous bone marrow transplantation (BMT)
    by request
  2. Allogeneic bone marrow transplantation (BMT)
    by request
  3. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  4. Targeted therapy
    by request
  5. Chemotherapy for leukemia
    by request
  6. Monoclonal antibodies therapy (mAbs)
    by request
  7. Hemicolectomy
    ≈ $19,697
  8. Rectum anterior resection
    ≈ $16,618
  9. Radical prostatectomy
    ≈ $17,065
photo
Dubai, United Arab Emirates
Specializations: Thoracic surgery, Oncology
Languages: English, Arabic
Mediclinic City Hospital’s Comprehensive Cancer Centre (CCC), is Dubai’s most advanced facility for the diagnosis and treatment of cancer. Built in collaboration with Mediclinic Middle read more
Prices for popular procedures:
  1. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  2. Monoclonal antibodies therapy (mAbs)
    by request
  3. Sentinel node biopsy
    from $15,340
  4. Mohs surgery
    from $12,600
  5. Melanoma surgical removal
    from $5,720
  6. Removal of benign skin lesions
    ≈ $4,300
  7. Skin cancer surgery
    ≈ $5,076
  8. Laser therapy for skin lesions
    ≈ $3,970
  9. Cryotherapy for skin lesions
    ≈ $4,635
photo
Tel Aviv, Israel
Specializations: Oncology
Languages: English, Russian
In Melanoma Unit, immunological / biological treatments are also given on drugs that are not in the health basket under the supervision of senior oncologists. read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $5,174
  4. Autologous bone marrow transplantation (BMT)
    by request
  5. Allogeneic bone marrow transplantation (BMT)
    by request
  6. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  7. Targeted therapy
    by request
  8. Chemotherapy for leukemia
    by request
  9. Monoclonal antibodies therapy (mAbs)
    by request
photo
Medina, Saudi Arabia
Specializations: Vascular surgery, Thoracic surgery, Oncology
King Faisal Specialist Hospital & Research Centre (Gen. Org) Madinah (KFSH&RC-M) is the latest addition to our internationally recognized organization. Our mission at KFSH&RC-M is read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $10,524
  4. Autologous bone marrow transplantation (BMT)
    by request
  5. Allogeneic bone marrow transplantation (BMT)
    by request
  6. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  7. Targeted therapy
    by request
  8. Chemotherapy for leukemia
    by request
  9. Monoclonal antibodies therapy (mAbs)
    by request
photo
Toulouse, France
Specializations: Thoracic surgery, Oncology
Languages: English, German, Spanish; Castilian
The IUCT Oncopole comprises the Institut Claudius Regaud, a cancer center, and several teams from Toulouse University Hospital Center. The two institutions offer the expertise read more
Prices for popular procedures:
  1. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  2. Monoclonal antibodies therapy (mAbs)
    by request
  3. Radiation therapy
    by request
  4. Immune checkpoint inhibitors
    by request
  5. Natural killer (NK) cell therapy
    by request
photo
São Paulo, Brazil
Specializations: Oncology
Occupying a total area of ​​1,550 m2, we have an infrastructure specially built to ensure the well-being of patients during cancer treatment. Humanism was the read more
Prices for popular procedures:
  1. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  2. Targeted therapy
    by request
  3. Chemotherapy for leukemia
    by request
  4. Monoclonal antibodies therapy (mAbs)
    by request
  5. Brachytherapy for prostate cancer
    $5,129
  6. Stereotactic radiation therapy (SRT)
    $2,799
  7. Radioactive Iodine therapy for thyroid cancer
    $1,595
  8. Hemicolectomy
    $1,360 - $2,367
  9. Rectum anterior resection
    $1,360 - $2,367
photo
Kazan, Russia
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Oncology
GAUZ "Republican Clinical Oncological Dispensary of the Ministry of Health of the Republic of Tatarstan" named after Professor M.Z. Sigal "is one of the largest read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $10,524
  4. Autologous bone marrow transplantation (BMT)
    by request
  5. Allogeneic bone marrow transplantation (BMT)
    by request
  6. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  7. Targeted therapy
    by request
  8. Chemotherapy for leukemia
    by request
  9. Monoclonal antibodies therapy (mAbs)
    by request
photo
Marseille, France
Specializations: Vascular surgery, Thoracic surgery, Oncology
The Paoli-Calmettes Institute (IPC) is a center for the fight against cancer, a member of the Unicancer group , governed by the public health code. read more
Prices for popular procedures:
  1. Chemotherapy for leukemia
    by request
  2. Conization
    ≈ $2,074
  3. Open hysterectomy
    ≈ $2,568
  4. Loop electrosurgical excision procedure (LEEP)
    ≈ $1,155
  5. Total laparoscopic hysterectomy (TLH)
    $1,556
  6. Laparoscopic cholecystectomy
    ≈ $1,518
  7. Total gastrectomy
    ≈ $18,523
  8. Total thyroidectomy
    ≈ $4,781
  9. Cholecystectomy
    ≈ $3,065
photo
Reynosa, Mexico
Specializations: Cardiac surgery, Vascular surgery, Oncology
Languages: English
The quality of CHRISTUS MUGUERZA on the Mexican border At CHRISTUS MUGUERZA Hospital Reynosa we provide high quality medical services to the Tamaulipas border community read more
Prices for popular procedures:
  1. Chemotherapy for leukemia
    by request
  2. Hemicolectomy
    ≈ $4,518
  3. Rectum anterior resection
    ≈ $3,488
  4. Conization
    ≈ $735
  5. Open hysterectomy
    ≈ $1,644
  6. Loop electrosurgical excision procedure (LEEP)
    ≈ $411
  7. Total laparoscopic hysterectomy (TLH)
    ≈ $1,795
  8. Laparoscopic cholecystectomy
    ≈ $1,449
  9. Total gastrectomy
    ≈ $6,899
photo
Chittagong, Bangladesh
Specializations: Thoracic surgery, Oncology
Chattogram Maa-O-Shishu Hospital is a 650-bedded hospital, which includes Paediatrics Medicine, Neonatology, Pediatric Surgery, Paediatric Neorology, General Surgery, Obstetrics & Gynaecology, Medicine & it's sub-specialists. read more
Prices for popular procedures:
  1. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  2. Monoclonal antibodies therapy (mAbs)
    by request
  3. Lumpectomy
    $906
  4. Simple mastectomy
    from $1,232
  5. Subcutaneous mastectomy
    $1,293
  6. Needle biopsy
    ≈ $238
  7. Vacuum-assisted breast biopsy
    ≈ $868
  8. Partial mastectomy
    ≈ $1,749
  9. Radical mastectomy
    ≈ $3,560
photo
Banská Bystrica, Slovakia
Specializations: Orthopedic surgery, Oncology
Mammacentrum St. Agáty is a member of the SVET ZDRAVIA hospital network. It is a specialized hospital that comprehensively deals with the diagnosis and treatment read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $3,995
  4. Targeted therapy
    by request
  5. Total body irradiation (TBI)
    by request
  6. Chemotherapy for leukemia
    by request
  7. Cord blood stem cell transplantation
    by request
  8. Radical prostatectomy
    ≈ $10,209
  9. Transurethral resection of the prostate (TURP)
    ≈ $3,143
photo
Chennai, India
Specializations: Thoracic surgery, Orthopedic surgery, Oncology
The Cancer Institute (WIA), as you are aware, is a public charitable voluntary institute dedicated to the care of cancer for for the last 60 read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $10,892
  4. Chemotherapy for leukemia
    by request
  5. Cord blood stem cell transplantation
    by request
  6. Hemicolectomy
    $14,296
  7. Rectum anterior resection
    ≈ $17,245
  8. Radical prostatectomy
    ≈ $15,877
  9. Transurethral resection of the prostate (TURP)
    ≈ $6,156
photo
Melbourne, Australia
Specializations: Thoracic surgery, Orthopedic surgery, Oncology
Languages: Arabic, Croatian, Italian, Serbian, Somali, Turkish, Vietnamese, Spanish; Castilian, Chinese, Greek, Modern
St Vincent’s Hospitals Australia has a rich tradition of providing progressive and excellent health care. We combine the latest technology with exceptional and compassionate medical, read more
Prices for popular procedures:
  1. Autologous bone marrow transplantation (BMT)
    by request
  2. Allogeneic bone marrow transplantation (BMT)
    by request
  3. Chemotherapy for leukemia
    by request
  4. Hemicolectomy
    ≈ $17,112
  5. Rectum anterior resection
    ≈ $18,465
  6. Radical prostatectomy
    ≈ $16,609
  7. Transurethral resection of the prostate (TURP)
    ≈ $7,884
  8. Conization
    ≈ $3,429
  9. Open hysterectomy
    ≈ $5,324
photo
Paris, France
Specializations: Thoracic surgery, Orthopedic surgery, Oncology
The Ambroise Paré, Pierre Cherest and Hartmann Clinics bring together specialized multidisciplinary teams. Regarding the financial aspect of care, every effort is made to ensure read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $5,265
  4. Autologous bone marrow transplantation (BMT)
    by request
  5. Allogeneic bone marrow transplantation (BMT)
    by request
  6. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  7. Targeted therapy
    by request
  8. Chemotherapy for leukemia
    by request
  9. Monoclonal antibodies therapy (mAbs)
    by request
photo
Buenos Aires, Argentina
Specializations: Cardiac surgery, Thoracic surgery, Orthopedic surgery, Oncology
As of March 14, 1994, the Alexander Fleming Institute opened its doors to medical and scientific excellence. Maximum technical-scientific level and comfort in one of read more
Prices for popular procedures:
  1. Chemotherapy for leukemia
    by request
  2. Hemicolectomy
    ≈ $13,909
  3. Rectum anterior resection
    ≈ $17,245
  4. Radical prostatectomy
    ≈ $15,877
  5. Transurethral resection of the prostate (TURP)
    ≈ $6,156
  6. Conization
    ≈ $3,222
  7. Open hysterectomy
    ≈ $8,418
  8. Loop electrosurgical excision procedure (LEEP)
    ≈ $1,750
  9. Total laparoscopic hysterectomy (TLH)
    ≈ $8,571
photo
Werribee, Australia
Specializations: Vascular surgery, Thoracic surgery, Orthopedic surgery, Oncology
Mercy Health – Health Services provides care for people in hospitals, clinics and community-based healthcare facilities in Victoria and southern New South Wales.Werribee Mercy Hospital read more

Clinics grouping by rating

Clinic with the highest rating of 5 — Berkana clinic in Moscow, Russia and 3 more, clinic with the most reviews number of 35757 — Aster CMI hospital in Bengaluru, India.

With rating 4.0 and over — 249 clinics .

Countries with the highest number of clinics treating the diseases:

Chronic lymphocytic leukemia (CLL):

Related procedures:

Chronic Lymphocytic Leukemia: Diagnostic and Treatment Management

Introduction & Classification of Chronic Lymphoid Leukemia

Chronic Lymphocytic Leukemia (CLL) is a type of cancer that affects the blood and bone marrow and is characterized by the overproduction of abnormal lymphocytes, a type of white blood cell.

CLL is the most common form of leukemia in adults, primarily affecting older individuals with a median age of diagnosis around 70 years. It is more common in men than women, with a male-to-female ratio of approximately 1.7:1. In the United States, it is estimated that there will be about 21,250 new cases of CLL and about 4,320 deaths from the disease in 2024 [seer.cancer.gov].

CLL is classified based on the characteristics of the lymphocytes and the genetic mutations they harbor [D'Arena et al., 2024]. The main subtypes include:

  • Typical CLL is the most common form and typically progresses slowly. Typical CCL patients with mutated immunoglobulin heavy chain variable region (IGHV) genes generally have a better prognosis.
  • Atypical CLL may have more aggressive clinical behavior and distinct cellular morphology, such as CD38 cellular surface protein positivity and unmutated IGHV.
  • Prolymphocytic Leukemia (PLL) is an aggressive form of CLL characterized by a higher number of prolymphocytes >55% in the blood and often requires more intensive treatment than typical CLL.

Stages of CLL

There are two basic staging systems for CLL – Rai and Binet; and one prognostic system for meta-staging called the CLL International Prognostic Index (CLL-IPI), released in 2016 [lls.org].

The Rai staging system monitors the range of abnormal increases in lymphocyte numbers as a primary risk assessment criteria:

  • Low Risk (Stage 0): Abnormal increase in the number of lymphocytes in the blood and marrow
  • Intermediate Risk (Stage I & II):
  • Abnormal increase in the number of lymphocytes in the circulating blood and the marrow PLUS enlarged lymph nodes
  • OR Abnormal increase in lymphocytes in the circulating blood and the marrow PLUS Enlarged spleen and/or liver.
  • High Risk (Stages III & IV):
  • Abnormal increase in the number of lymphocytes in the circulating blood and the marrow PLUS anemia (hemoglobin <11g/dL)
  • OR Abnormal increase in the number of lymphocytes in the circulating blood and the marrow PLUS thrombocytopenia (platelet counts <100,000/uL).

On the other hand, the Binet Staging System registers positive or negative changes in the level of red blood cells (hemoglobin count) and platelets:

  • Stage A: no anemia (hemoglobin ≥10g/dL), no thrombocytopenia (platelets ≥100,000/mm<sup>3</sup>), and less than three areas of lymphoid tissue enlargement.
  • Stage B: no anemia (hemoglobin ≥10g/dL), no thrombocytopenia (platelets ≥100,000/mm<sup>3</sup>), and three or more areas of lymphoid tissue enlargement.
  • Stage C: anemia (hemoglobin <10g/dL), thrombocytopenia (platelets <100,000/mm<sup>3</sup>), any number of areas of lymphoid tissue enlargement

Meanwhile, the CLL-IPI combines five independent prognostic factors:

  • TP53 gene deleted or mutated = 4 points
  • Unmutated IGHV = 2 points
  • Serum beta-2 microglobulin concentration > 3.5 mg/L = 2 points
  • Rai Stage I - V or Binet Stage B - C = 1 point
  • Patient age > 65 years = 1 point

According to CLL-IPI "low risk" category is 0-1 point (do not treat recommendations), "intermediate risk" is 2-3 points (do not treat unless the disease is highly symptomatic), "high risk" - 4-6 points (treat unless the patient is asymptomatic), "very high risk" – 7-10 (use novel agents rather than chemotherapy).

Algorithm of Diagnosis

What evaluations do CLL patients undergo to identify the best treatment strategy?

The diagnosis of CLL is established by immunophenotyping of peripheral blood – detecting the presence of ≥5 × 10<sup>9</sup>/l monoclonal B lymphocytes with the clonality of the cells confirmed by demonstrating light chain restriction using flow cytometry. LN biopsy and/or bone marrow biopsy may be helpful if immunophenotyping is not conclusive for the diagnosis [ESMO, 2021].

The following diagnostic work-up serves as a tool for the precise staging of CLL and includes:

  • Cytogenetics (FISH) and molecular genetics for TP53 mutation or del(17p);
  • GHV mutational status;
  • Complete blood count and differential;
  • Physical examination.

Phases of Treatment

How is CLL treatment structured?

Watchful Waiting

For patients with early-stage CLL (Rai stage 0, I, or Binet stage A) who are asymptomatic, immediate treatment may not be necessary. Instead, a watchful waiting approach is often adopted, regularly monitoring blood counts and clinical status. Additionally, imaging methods, such as CT scans and MRI, can be used for symptomatic pulmonary / pelvic / neck patients.

First-Line Treatment

What are the initial treatments for CLL?

For CLL at advanced Rai stage II-IV or Binet stage B-C, Bruton tyrosine kinase inhibitors (BTKis) such as ibrutinib are used until the progression of the disease. In addition, the United States Food and Drug Administration (FDA) and European Medicines Agency (EMA) have recently approved the combination of venetoclax plus obinutuzumab as first-line therapy for CLL with TP53 gene or del(17p) mutations [ESMO, 2021].

Second-Line Treatment

What options are available if initial treatments fail?

For patients whose disease progresses after first-line therapy, second-line treatments are available:

  1. Targeted Therapy: Continued use of BTK inhibitors (ibrutinib, acalabrutinib) or switching to venetoclax-based regimens.
  2. Immunotherapy:
    • CAR-T Cell Therapy: Chimeric Antigen Receptor T-cell therapy, where a patient's T-cells are modified to target CLL cells.
    • Alemtuzumab: An anti-CD52 antibody for patients with heavily pretreated CLL.
  3. Stem Cell Transplantation: Allogeneic stem cell transplantation may be considered for younger patients with high-risk disease or those with refractory CLL.

Prognosis and Survival Rates

What are the survival rates and factors affecting prognosis?

Generally, from all people with CLL, around 85% of individuals will survive their CLL for five years or more after being diagnosed. This applies to all ages. However, age does seem to play a role in five-year survival outcomes:

  • for those younger than 60 - 95% will survive;
  • for those aged between 60 and 69 – 90%;
  • for those aged between the ages of 70 and79 – more than 80%;
  • for those who are 80 or older – around 65%.

Additionally, there is a statistics published by Cancer Research UK on five-year survival rates connected to the Chronic Lymphocytic Leukaemia International Prognostic Index (CLL-IPI):

  • Low-risk group – 95% of patients will survive;
  • Intermediate risk group – 80%;
  • High-risk group – 65%;
  • Very high-risk group – 25.

Follow-Up and Monitoring

How do you ensure continued health after treatment?

During follow-up strategy in patients with CLL in remission, according to the European Society for Medical Oncology (ESMO), there are CBC, physical examination, and serum chemistry (including serum immunoglobulin and direct antiglobulin test) every three to twelve months in asymptomatic patients [ESMO, 2021].

  • Alejandro Santos, M.D.
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