Aggressive non-Hodgkin lymphoma (NHL) treatment in 760 Oncology clinics worldwide

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760 clinics specializing in Oncology providing treatment of Aggressive non-Hodgkin lymphoma (NHL) Aggressive non-Hodgkin lymphoma (NHL) is a fast-growing cancer that affects the lymphatic system. It can cause enlarged lymph nodes, fever, night sweats, weight loss, and may require intensive chemotherapy, radiation therapy, or stem cell transplant for treatment.
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disease worldwide.

Africa · 11
Americas · 168
Asia · 231
Europe · 316
Oceania · 34
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Africa · 11 Americas · 168 Asia · 231 Europe · 316 Oceania · 34
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Prices for popular procedures:
  1. Splenectomy
    ≈ $16,900
  2. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  3. Natural killer (NK) cell therapy
    by request
  4. Monoclonal antibodies therapy (mAbs)
    by request
  5. Gamma Knife
    $16,726
  6. Hemicolectomy
    $27,730
  7. Rectum anterior resection
    ≈ $19,845
  8. Radical prostatectomy
    ≈ $17,098
  9. Transurethral resection of the prostate (TURP)
    ≈ $12,436
photo
Seoul, South Korea
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology, Dentistry
The hospital is fully devoted to elevating its medical service quality by introducing state-of-the-art equipment and systems such as Robot surgery, Linear Accelerator, 3.0T MRI, read more
Prices for popular procedures:
  1. Splenectomy
    $1,423
  2. Hemicolectomy
    $2,931
  3. Rectum anterior resection
    $3,369
  4. Radical prostatectomy
    ≈ $608
  5. Transurethral resection of the prostate (TURP)
    $1,216
  6. Conization
    $182 - $231
  7. Open hysterectomy
    $1,338
  8. Radical nephrectomy
    $1,228 - $1,958
  9. Loop electrosurgical excision procedure (LEEP)
    ≈ $457
photo
Almaty, Kazakhstan
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology, Dentistry
Languages: English, Russian
At the Almaty SEMA Hospital Clinic, you can get a full range of medical services provided by our leading specialists. Whether you need a small read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $2,033
  4. Chemotherapy for lymphoma
    by request
  5. Cord blood stem cell transplantation
    by request
  6. Hemicolectomy
    ≈ $3,335
  7. Rectum anterior resection
    ≈ $3,204
  8. Radical prostatectomy
    ≈ $672
  9. Transurethral resection of the prostate (TURP)
    ≈ $2,169
photo
Lajeado, Brazil
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Orthopedic surgery, Oncology
Bruno Born Hospital is a philanthropic institution, with more than 80 years. It is registered with the National, State and Municipal Councils of Social Assistance read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $2,033
  4. Autologous bone marrow transplantation (BMT)
    by request
  5. Allogeneic bone marrow transplantation (BMT)
    by request
  6. Chemotherapy for lymphoma
    by request
  7. Cord blood stem cell transplantation
    by request
  8. Hemicolectomy
    ≈ $3,335
  9. Rectum anterior resection
    ≈ $3,204
photo
São Paulo, Brazil
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​ Hospital São Camilo Pompeia has followed, over the years, the growth of the population and the scientific and technological advances aimed at medical and read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $2,033
  4. Autologous bone marrow transplantation (BMT)
    by request
  5. Allogeneic bone marrow transplantation (BMT)
    by request
  6. Chemotherapy for lymphoma
    by request
  7. Cord blood stem cell transplantation
    by request
  8. Hemicolectomy
    ≈ $3,335
  9. Rectum anterior resection
    ≈ $3,204
photo
São Paulo, Brazil
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
Integrated into the São Camilo de São Paulo Hospitals Network in March 1979, the Santana Unit has an agile and modern structure implemented to offer read more
Prices for popular procedures:
  1. Chemotherapy for lymphoma
    by request
  2. Childhood vascular tumor treatment
    ≈ $478
  3. Thoracoplasty including sternoplasty
    ≈ $2,713
  4. Diagnostic thoracoscopy
    ≈ $1,147
  5. Carotid endarterectomy (CEA)
    ≈ $2,847
  6. Repair of diaphragmatic hernia
    ≈ $2,681
  7. Laminectomy
    ≈ $3,492
  8. Peripheral artery angioplasty and stent placement
    ≈ $2,837
  9. Abdominal endovascular aneurysm repair (EVAR)
    ≈ $9,175
photo
São Paulo, Brazil
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
A member of the Network since 2000, Hospital São Camilo Ipiranga has an emergency room for patients aged 12 years and over, an Intensive Care read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $2,033
  4. Autologous bone marrow transplantation (BMT)
    by request
  5. Allogeneic bone marrow transplantation (BMT)
    by request
  6. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  7. Natural killer (NK) cell therapy
    by request
  8. Total body irradiation (TBI)
    by request
  9. Chemotherapy for lymphoma
    by request
photo
São Paulo, Brazil
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
Founded in 1968, the Mooca unit is known for being a highly complex Oncological Treatment Center and for having a renowned Clinical Research Center. In read more
Prices for popular procedures:
  1. Autologous bone marrow transplantation (BMT)
    by request
  2. Allogeneic bone marrow transplantation (BMT)
    by request
  3. Chemotherapy for lymphoma
    by request
  4. Hemicolectomy
    ≈ $3,335
  5. Rectum anterior resection
    ≈ $3,204
  6. Radical prostatectomy
    ≈ $672
  7. Transurethral resection of the prostate (TURP)
    ≈ $2,169
  8. Conization
    ≈ $694
  9. Open hysterectomy
    ≈ $2,037
photo
Rio de Janeiro, Brazil
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
The Quinta D'Or Hospital opened in September 2001 and is located opposite Quinta da Boa Vista, in Rio de Janeiro. It emerged from the renovation read more
Prices for popular procedures:
  1. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  2. Natural killer (NK) cell therapy
    by request
  3. Targeted therapy
    by request
  4. Chemotherapy for lymphoma
    by request
  5. Monoclonal antibodies therapy (mAbs)
    by request
  6. Chemotherapy for melanoma
    by request
  7. Chemotherapy for endometrial cancer
    by request
  8. Chemotherapy for gallbladder cancer
    by request
  9. Chemotherapy for colorectal cancer
    by request
photo
Belo Horizonte, Brazil
Specializations: Oncology
Founded in 1999, Oncocentro was born with the purpose of offering an integral, welcoming and interdisciplinary service. Over the years, it has become a reference read more
Prices for popular procedures:
  1. Chemotherapy for lymphoma
    by request
  2. Parotidectomy
    ≈ $1,332
  3. Cervical lymphadenectomy
    ≈ $2,014
  4. Total glossectomy
    ≈ $1,766
  5. Oral cancer surgery
    ≈ $3,649
  6. Hemiglossectomy
    ≈ $1,333
  7. Submandibular gland resection
    ≈ $948
  8. Lip resection
    ≈ $1,269
  9. Floor of mouth cancer resection
    ≈ $779
photo
Belo Horizonte, Brazil
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
The Lifecenter Hospital stands out among the most sophisticated and renowned health institutions in Minas Gerais. Its activities cover urgent and emergency medical care, surgeries, read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $2,033
  4. Chimeric antigen receptor (CAR) T-cell therapy
    by request
  5. Natural killer (NK) cell therapy
    by request
  6. Targeted therapy
    by request
  7. Chemotherapy for lymphoma
    by request
  8. Monoclonal antibodies therapy (mAbs)
    by request
  9. Cord blood stem cell transplantation
    by request
photo
Salvador, Brazil
Specializations: Vascular surgery, Thoracic surgery, Neurosurgery, Oncology
Founded 30 years ago, the Oncology Nucleus of Bahia (NOB) joined the Oncoclínicas Group in 2014. The clinic offers comprehensive and individualized care to cancer read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $5,301
  4. Chemotherapy for lymphoma
    by request
  5. Cord blood stem cell transplantation
    by request
  6. Hemicolectomy
    ≈ $9,864
  7. Rectum anterior resection
    ≈ $10,153
  8. Radical prostatectomy
    ≈ $8,687
  9. Transurethral resection of the prostate (TURP)
    ≈ $4,255
photo
Buenos Aires, Argentina
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
We invite you to visit one of the largest health institutions in the country… A sanatorium with history, but looking to the future. The Doctor read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $5,301
  4. Autologous bone marrow transplantation (BMT)
    by request
  5. Allogeneic bone marrow transplantation (BMT)
    by request
  6. Chemotherapy for lymphoma
    by request
  7. Cord blood stem cell transplantation
    by request
  8. Radical prostatectomy
    ≈ $8,687
  9. Transurethral resection of the prostate (TURP)
    ≈ $4,255
photo
Buenos Aires, Argentina
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
The British Hospital of Buenos Aires is a non-profit civil association that aims to provide the community with highly complex health care, train medical professionals read more
Prices for popular procedures:
  1. Chemotherapy for lymphoma
    by request
  2. Hemicolectomy
    ≈ $3,335
  3. Rectum anterior resection
    ≈ $3,204
  4. Radical prostatectomy
    ≈ $672
  5. Transurethral resection of the prostate (TURP)
    ≈ $2,169
  6. Conization
    ≈ $694
  7. Open hysterectomy
    ≈ $2,037
  8. Radical nephrectomy
    ≈ $4,597
  9. Loop electrosurgical excision procedure (LEEP)
    ≈ $416
photo
Serra, Brazil
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Orthopedic surgery, Oncology
Founded in 2001, Vitória Apart Hospital is a center of excellence in high complexity medicine in Espírito Santo, prepared to take care of people's health read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $5,301
  4. Autologous bone marrow transplantation (BMT)
    by request
  5. Allogeneic bone marrow transplantation (BMT)
    by request
  6. Chemotherapy for lymphoma
    by request
  7. Cord blood stem cell transplantation
    by request
  8. Radical prostatectomy
    ≈ $8,687
  9. Transurethral resection of the prostate (TURP)
    ≈ $4,255
photo
Buenos Aires, Argentina
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
The Hospital de Clínicas José de San Martín is the flagship teaching hospital in our country. Dependent on the University of Buenos Aires, read more
Prices for popular procedures:
  1. Chemotherapy for lymphoma
    by request
  2. Childhood vascular tumor treatment
    ≈ $736
  3. Orbital tumor temoval
    ≈ $17,452
  4. Dual chamber pacemaker insertion
    ≈ $7,079
  5. Arteriovenous (AV) fistula surgery
    ≈ $2,082
  6. Endovascular thrombectomy
    ≈ $3,688
  7. Brain tumors surgery
    ≈ $10,285
  8. Hip osteotomy
    ≈ $4,664
  9. Arthroscopic meniscus repair
    ≈ $2,320
photo
Buenos Aires, Argentina
Specializations: Cardiac surgery, Vascular surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
The Ricardo Gutiérrez Children's Hospital is a highly complex, tertiary, reference hospital for the entire country and neighboring countries. Since its creation, in 1875, it read more
Prices for popular procedures:
  1. Autologous bone marrow transplantation (BMT)
    by request
  2. Allogeneic bone marrow transplantation (BMT)
    by request
  3. Chemotherapy for lymphoma
    by request
  4. Childhood vascular tumor treatment
    ≈ $736
  5. Coronary artery bypass graft (CABG)
    ≈ $18,185
  6. Laminectomy
    ≈ $8,490
  7. Peripheral artery angioplasty and stent placement
    ≈ $5,524
  8. Arteriovenous (AV) fistula surgery
    ≈ $2,082
  9. Endovascular thrombectomy
    ≈ $3,688
photo
Buenos Aires, Argentina
Specializations: Cardiac surgery, Vascular surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
The Hospital "Prof. Dr. Juan P. Garrahan" is the pediatric center of reference in public health, free and highly complex in Argentina. Since its inauguration, read more
Prices for popular procedures:
  1. Chemotherapy for lymphoma
    by request
  2. Heart valve replacement
    ≈ $25,934
  3. Heart valve repair
    ≈ $22,380
  4. Aortic valve replacement (AVR)
    ≈ $25,184
  5. Mitral valve replacement (MVR)
    ≈ $19,322
  6. Transcatheter aortic valve replacement (TAVR)
    ≈ $34,413
  7. Varicose veins treatment
    ≈ $4,586
  8. Brain aneurysm repair
    ≈ $11,954
  9. Brain aneurysm clipping
    ≈ $11,765
photo
Buenos Aires, Argentina
Specializations: Cardiac surgery, Vascular surgery, Neurosurgery, Orthopedic surgery, Oncology
On July 24, 1896, the Pirovano Hospital (which was to be called Belgrano Hospital) opened its doors to ensure the assistance of an original population read more
Prices for popular procedures:
  1. Stem cell transplant (peripheral blood)
    by request
  2. Hematopoietic stem cell harvest
    by request
  3. Splenectomy
    ≈ $5,301
  4. Chemotherapy for lymphoma
    by request
  5. Cord blood stem cell transplantation
    by request
  6. Radical prostatectomy
    ≈ $8,687
  7. Transurethral resection of the prostate (TURP)
    ≈ $4,255
  8. Conization
    ≈ $1,992
  9. Open hysterectomy
    ≈ $3,660
photo
Rosario, Argentina
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
More than 100 years ago, on June 24, 1912, the Spanish Hospital was inaugurated in Rosario, driven by the demand for health care from Spanish read more
Prices for popular procedures:
  1. Chemotherapy for lymphoma
    by request
  2. Radical prostatectomy
    ≈ $8,687
  3. Transurethral resection of the prostate (TURP)
    ≈ $4,255
  4. Conization
    ≈ $1,992
  5. Open hysterectomy
    ≈ $3,660
  6. Radical nephrectomy
    ≈ $9,523
  7. Loop electrosurgical excision procedure (LEEP)
    ≈ $1,079
  8. Total laparoscopic hysterectomy (TLH)
    ≈ $4,331
  9. Parotidectomy
    ≈ $2,818
photo
Buenos Aires, Argentina
Specializations: Cardiac surgery, Vascular surgery, Thoracic surgery, Neurosurgery, Spine surgery, Orthopedic surgery, Oncology
The Pueyrredon Private Clinic was born in response to the need of Mar del Plata doctors who worked at that time as professionals in mutual read more

Clinics grouping by rating

Clinic with the highest rating of 5 — Berkana clinic in Moscow, Russia and 4 more, clinic with the most reviews number of 35757 — Aster CMI hospital in Bengaluru, India.

With rating 4.0 and over — 252 clinics .

Countries with the highest number of clinics treating the diseases:

Aggressive non-Hodgkin lymphoma (NHL):

Related procedures:

Diffuse Large B-Cell Lymphoma: Overview and Treatment Management

Introduction & Overview of Diffuse Large B-Cell Lymphoma

Diffuse Large B Cell Lymphoma (DLBCL) is a type of non-Hodgkin lymphoma (NHL), making up about one-third of all B cell NHL instances in the United States. Reports suggest there are 18,000 DLBCL cases annually [SEER].

This form of lymphoma can develop within or outside lymph nodes, impacting organs like the spleen, liver, and bone marrow. While DLBCL mainly affects individuals typically diagnosed around age 66, it can also manifest in children and young adults [Cancer Research UK].

DLBCL isn't an ailment but rather a cluster of cancers with two primary subcategories [Padala et al., 2023]:

    1. Germinal Center B-cell-like (GCB) DLBCL arises from B cells located in the centers of lymph nodes. Patients with this subtype often exhibit improved responses to chemotherapy treatments compared to ABC DLBCL – 83% vs 13%, respectively [Dunleavy and Wilson, 2014]. Prognostically, individuals with the GCB subtype generally fare better than those with the ABC subtype due to variances in the cancer cells' fundamental biology.
    2. Activated B-cell (ABC) DLBCL originates from B-cells transitioning into plasma cells, which is associated with a poor prognosis due to an overactive inflammatory molecule mediator called nuclear factor kappa B.

There are some common subtypes of DLBCL as per the ESMO Consensus;

    1. Primary Mediastinal B-cell Lymphoma (PMBCL) is typically seen in young adults and affects the chest area.
    2. CNS Lymphoma affects the brain and spinal cord.
    3. Transformed DLBCL can occur when a growing lymphoma transforms into a more aggressive form, such as follicular lymphoma (FL), chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), or nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). These transformed lymphomas usually require more intensive types of treatment.

To confirm a diagnosis of DLBCL, doctors typically need to perform a biopsy by collecting a sample from the lymph node and examining it under a microscope. This procedure can be carried out under general anesthesia. Following the confirmation of diagnosis, determining the disease location in the body through staging becomes crucial since DLBCL is considered a type of blood cancer that may manifest across parts of the body [Cancer.net].

Doctors often conduct these tests using a positron emission tomography (PET) scan, which involves injecting a dye into the patient to pinpoint the location of cancer. Other diagnostic procedures may be part of the panel, such as a bone marrow biopsy to check for cancer in the bones or a spinal tap to examine the fluid around the brain and spinal cord for signs of cancer in the CNS system. The results from these tests help physicians determine the stage of lymphoma. The Ann Arbor staging system is utilized to categorize the extent of lymphoma, ranging from Stage I involving one lymph node or extralymphatic organ to Stage IV involving organs beyond lymph nodes.

Phases of Treatment

How is the treatment plan for DLBCL structured?

The treatment for DLBCL usually starts after the diagnosis. The goal is to achieve lasting remission or even a cure. A common approach involves using a mix of chemotherapy and a specific type of antibody that targets CD20, a protein in lymphoma cells. Rituximab (Rituxan) is an anti-CD20 antibody administered through intravenous infusion. For some patients, Rituxan Hycela, a form of rituximab injected under the skin, may also be considered [based on ESMO Guidelines].

Limited Stage (Stage) DLBCL

First Line Therapy

• The R-CHOP Regimen is the standard and the most common initial treatment, which consists of Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone. This combination is typically given in cycles lasting 21 days each. Repeated for a total of 6 cycles.

• Involved Site Radiotherapy (ISRT) - often combined with chemotherapy to improve control and outcomes in 60+ years patients with two relapse episodes or low-intermediate International Prognostic Index (IPI risk), which is a combination of stage III-IV of DLBCL, more than one extranodal sites involvement and / or slightly decreased performance status.

Intermediate Stage and Advanced Stage DLBCL

First Line Treatment

• R-CHOP or EPOCH-R chemotherapy. The standard approach for patients with the disease is R-CHOP, though high-risk patients might benefit from EPOCH R, which includes Etoposide and the standard R-CHOP medications in 6 cycles.

Second Line Treatment

• Salvage therapy for patients who relapse or do not respond to treatment includes Polatuzumab Vedotin combined with Bendamustine and Rituximab (BR) or dose chemotherapy followed by autologous stem cell transplant.

Recurrent or Treatment-resistant DLBCL

CAR T-Cell Therapy:

• Yescarta (Axicabtagene Ciloleucel) and Kymriah (Tisagenlecleucel) are the treatments that involve modifying the patient's T-cells to target the lymphoma cells and are used for patients who do not respond to at least two previous treatments. The CAR T-Cell Therapy may be combined with more intensive platinum-based chemotherapy regimens with cisplatin, gemcitabine, and high-dose cytarabine.

Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL)

• Observation Approach: Sometimes treatment may not be needed for NLPHL, so doctors opt for a waiting strategy. This involves check-ups and starting treatment only if the condition worsens.

Targeted Treatment

• Adcetris (Brentuximab Vedotin) is used in cases where NLPHL recurs, combining therapy with chemotherapy.

• Opdivo (Nivolumab) and Keytruda (Pembrolizumab) help boost the system's response to cancer cells, and they are being studied in terms of types of lymphomas.

Assessing Response

Evaluating how well the treatment works involves repeated PET scans to see if the lymphoma has shrunk or become less active. The aim is remission (CR), which means there are no signs of the disease.

Prognosis, Survival Rates, and Monitoring

What are the chances of survival, and what factors influence outlook?

The five-year survival rate varies depending on the stage of the disease and other factors. Generally, it ranges from 60-70% for early-stage disease to 50% for advanced stages.

Moreover, data on outcomes provided by the National Cancer Institute indicate a correlation with age, showing a prognosis of 80% for patients under 55, 70% for those aged 55-64, and 55% for individuals over 65 [SEER].

Consistent monitoring is essential to detect relapses and address long-term side effects, as highlighted by the Lymphoma Research Foundation:

1. Initial check-ups: Typically scheduled every three months during the two years after treatment involving examinations and necessary imaging.

2. Ongoing follow-up visits every six months from years three to five, and then after that to address survivorship concerns and screen for potential secondary cancers.

  • Alejandro Santos, M.D.
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